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Destroying Amyloid Fibers With Lasers
Researchers have found that a technique used to visualize amyloid fibers in the laboratory might have the potential to destroy them in the clinic.
Amyloid fibers are best known as the plaque that tangles up neurons in people with neurodegenerative illnesses such as Alzheimer’s. The technique involves zapping the fluorescently-tagged fibers with a laser, which can inhibit their growth and degrade them. This study may offer a non-drug alternative to treat amyloid-based disorders like Alzheimer’s.
Yuji Goto and colleagues had been studying amyloids, dense tangles of protein, to better understand how they form. In an effort to view amyloid formation under a microscope in real-time, they added an amyloid specific dye called thioflavin T (ThT) to the tangles and then hit it with a laser beam to induce fluorescence.
Surprisingly, they found that under the right conditions, the laser could actually stop fiber growth and even degrade the amyloids.
Goto and colleagues believe the laser-excited ThT transfers some of its energy to nearby oxygen, resulting in active oxygen species that alters the surrounding protein fibers. These specific experiments focused on beta2-microglobulin, a major component of amyloids associated with dialysis-related amyloidosis (a condition that currently has no good treatment), though they believe a similar approach of light-induced decomposition should work for other types of protein amyloids.
This video shows real-time monitoring of the disappearance of preformed amyloid fibrils, intermittently irradiated with a laser beam.
Source:
Daisaku Ozawa, et al. Destruction of Amyloid Fibrils of a β2-Microglobulin Fragment by Laser Beam Irradiation. Journal of Biological Chemistry.
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Researchers have found that a technique used to visualize amyloid fibers in the laboratory might have the potential to destroy them in the clinic.
